Combating Acanthamoeba spp. cysts: what are the options?

Combating Acanthamoeba spp. cysts: what are the options?

Blog Article

Abstract Acanthamoeba spp.are protist pathogens and causative agents of serious infections including keratitis and granulomatous amoebic encephalitis.Its ability to convert into dormant and highly resistant cysts form limits effectiveness of Hand and feet set available therapeutic agents and presents a pivotal challenge for drug development.During the cyst stage, Acanthamoeba is protected by the presence of hardy cyst walls, comprised primarily of carbohydrates and cyst-specific proteins, hence synthesis inhibition and/or degradation of cyst walls is of major interest.This review focuses on targeting of Balance Acanthamoeba cysts by identifying viable therapeutic targets.